Endocrine Abstracts

Case 1: Thirty-eight year woman consulted to gynecologist for oligomenorrhea in the last 4 years; PRL 51 μg/l and TSH 8.4 mU/l were discovered, initiating treatment with levotiroxine (f-T4). She got pregnant, persisting elevated levels of TSH and increasing f-T4, with normal campimetry. With the diagnostic of hyperthyroidism due to inadequate TSH secretion, treatment with PTU was initiated. After normal delivery, MRI showed a 22 mm. hypophisary macroadenoma and a transesp...

Insulin continuous s.c. infusion (ICSI) is an alternative therapy in selected diabetic patients when a good metabolic control is not achieved with multiple insulin doses (MID). We report the follow-up of patients with ICSI at least during 1 year in our centre.Patients and methods: Twenty-five patients (16 females, 9 males), with median age 38.4±12.5 years and diabetes evolution mean time 16.8±7.8 years, were changed from MID to ICSI due to defi...

Introduction: Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with an incidence of 1 in 2600 to 3000 individuals. Patients with this disorder are characterized by multiple neurofibromas, caf-au-lait macules, axillary freckling, optic gliomas, iris hamartomas, and skeletal abnormalities. Overall risk of developing neoplasms is approximately 2 to 4-fold higher in patients with NF1, with a risk of malignancy estimated between 5 and 15%. Endocrinopathies are some...

Introduction: Clinically non-functioning pituitary adenomas (NFPA) are heterogeneous group. Some previous research has found that this type of pituitary adenomas may be smaller and have better prognostic in men. The aim of this study is to analyze if there are gender-related differences in NFPA.Material and methods: Retrospective study of patients with NFPA followed up in regional hospitals (Community of Madrid, Spain). All NFPA had molecular analysis. T...

Objective: Study of the efficacy of SSA in the biochemical and tumour control and the relation between the T2-weighted MRI signal intensity and the response to SSA.Material and methods: 16 patients with GH-secreting pituitary adenomas (7♂/9♀) that received primary or pre-operative treatment with SSA. We classified them according to baseline T2-weighted MRI sequences as Hypo-intense (Ha) and No-Hypo-intense adenomas (no-Ha). Results expressed ...

Introduction: Although the most common causes of hyperprolactinemia are prolactinoma and iatrogenic, another possible cause is severe primary hypothyroidism, in which the increase of prolactin is a cause of pituitary stimulation by TRH, and can be presented with pituitary hyperplasia.Case report: A 31-year-old woman who comes to endocrinology clinic for hyperprolactinemia, which was detected by symptoms of amenorrhea–galactorrhea. After normal pregn...

Introduction: Allergy is an uncommon side-effect of insulin treatment in which desensitization represents an alternative when initial approaches are not effective. Autoimmune pancreatitis (AIP) is an even more rare disease that generally has a successful response to corticosteroids. The case of a 50-year-old diabetic man who developed both processes sequentially is presented.Case report: The patient was admitted for acute diabetes mellitus (DM) decompens...

Medical treatment of acromegaly is currently performed through a trial-error manner using somatostatin receptor ligands (SRLs) as first-line drugs. Average SRLs response is seen in 50% of cases; subsequent drugs are indicated following clinical judgement. Some biomarkers either before or after surgical failure have been reported to predict SRLs response, including intensity in T2 weighted MRI, short acute octreotide test (sAOT), and different molecules such as SST2 and E-cadhe...